The Synthesis of Hemoglobin in a Cell-free System.

28 J. C. Kendrew, G. Bodo, H. M. Dintzis, R. G. Parrish, H. Wykoff, and D. C. Phillips, Nature, 181, 660, 1958. 29 See J. Wyman, Jr., Advances in Protein Chem., 4, 410, 1948. 30 P. George and G. I. H. Hanania, Biochem. J., 52, 517, 1952. 31 P. George and G. I. H. Hanania, ibid., 55, 236, 1953. 32 H. Theorell, J. Am. Chem. Soc., 63, 1812, 1820, 1941. 33 See J. T. Edsall and J. Wyman, Jr., Biophysical Chemistry (New York: Academic Press, IDC., 1958),1, 464. 34 The formulas Pr-Fe+-Y, etc., used previously to denote reactions where the group has a "high" proton affinity, will now be employed for the general case. 3' H. Theorell and K. G. Paul, Ark. Kemie, Mineral., Geol., 18A, No. 12, 1, 1944. 36 J. M. Kolthoff and W. J. Tomsicek, J. Phys. Chem., 39, 955, 1935. 37 P. George and G. I. H. Hanania, Nature, 174, 33, 1954. 38 P. George and R. L. J. Lyster in Conference on Hemoglobin, May 2-3, 1957 (Washington: National Academy of Sciences-National Research Council, 1957) (NAS-NRC Publication No. 557), 1958, p. 33. 39 R. Havemann and W. Rausch, Z. phys. Chem., 202, 400, 1954. 40 R. Havemann and P. Wolf, Z. phys. Chem., 201, 246, 1952. 41 W. Scheler, A. Salewski, and F. Jung, Biochem. Z., 326, 288, 1955. 42 P. George and A. Adler, unpublished observations. 43 P. George, R. L. J. Lyster, and J. Beetlestone, Nature, 181, 1534, 1958. 44 D. Crowfoot Hodgkin, J. Pickworth, J. H. Robertson, K. N. Trueblood, R. J. Prosen, J. G. White, R. Bonnet, J. R. Cannon, A. W. Johnson, I. Sutherland, A. R. Todd, and E. Lester Smith, Nature, 176, 325, 1955. 45 F. Haurowitz, in Hemoglobin-Barcroft Memorial Conference (London: Butterworths Scientific Publications, 1949), p. 53. 46 See P. George in Currents in Biochemical Research, 1956, ed. D. E. Green (New York and London: Interscience Publishers, 1956), p. 338.